This weekend I head out to BaltiCon. This is my home town con and I will be covering it for the ConMen. I will also be sitting on several panels for gaming and new media. BaltiCon is a medium sized con and I enjoy it because it differs from most of the other cons I go to. GenCon, TotalCon, and OGC are all heavy gaming cons and Dragon*Con is a media con. BaltiCon is a science fiction con and has a huge new media portion to it. It also has a budding Skeptic track that I plan to participate in next year.
The down side to BaltiCon is that it is poorly organized. My events for GenCon are already locked in. Dragon*Con will be locked in in the next few weeks. Both TotalCon and OGC are small cons in comparison and they are handled far better. Hell, my OGC stuff is already locked in. How bad is it? Well, I just received my schedule for BaltiCon and it's 4 days away. Also, they have a game track that focuses on RPGs but almost zero RPG events. I might try to fix that as well next year but we'll see.
That said, BaltiCon is pretty cool and a lot of fun. Their are a ton of science track with some pretty qualified scientists. You may not know it but Maryland has a huge science community; especially medicine. But if you want to have the most fun meet me at the bar!
If you live anywhere near Baltimore you should swing down this weekend, check out the con and have some fun. If nothing else, find me in the bar in the evening chatting it up with the likes of Scott Sigler, George Hrab, and Paul Cooley. You mention Studio187 and I'll buy you a drink!